Download E-books Viral Membrane Proteins: Structure, Function, and Drug Design: 1 (Protein Reviews) PDF

In Viral Membrane Proteins: constitution, functionality, and Drug layout, Wolfgang Fischer summarizes the present structural and useful wisdom of membrane proteins encoded by means of viruses. moreover, participants to the publication tackle questions on proteins as strength drug pursuits. the variety of knowledge coated comprises sign proteins, ion channels, and fusion proteins. This booklet has a spot within the libraries of researchers and scientists in a wide range of fields, together with protein chemistry, molecular biophysics, pharmaceutical technological know-how and learn, bioanotechnology, molecular biology, and biochemistry.

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Four. precis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147 148 153 154 156 158 159 159 12. constitution, Phosphorylation, and organic functionality of the HIV-1 particular Virus Protein U (Vpu) Victor Wray and Ulrich Schubert 1. advent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. constitution and Biochemistry of Vpu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . three. Biochemical research of Vpu Phosphorylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 167 a hundred and seventy 173 thirteen. Solid-State NMR Investigations of Vpu Structural domain names in orientated Phospholipid Bilayers: Interactions and Alignment Burkhard Bechinger and Peter Henklein 1. advent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. Peptide Synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . three. effects and dialogue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177 179 181 185 185 14. Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1 V. Lemaitre, C. G. Kim, D. Fischer, Y. H. Lam, A. Watts, and W. B. Fischer 1. creation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1. 1. brief Viral Membrane Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1. 2. The Vpu Protein . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. The equipment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. 1. Docking method . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. 2. Molecular Dynamics (MD) Simulations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . three. research of Drug–Protein Interactions of Vpu with a possible Blocker . . . . . . . . . . . . . . . three. 1. utilizing the Docking strategy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . three. 2. using MD Simulations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 188 189 189 189 one hundred ninety a hundred ninety 191 192 x Contents four. How practical is the Protein version? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . five. The Putative Binding web site . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6. Water within the Pore . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7. MD Simulations for Drug Screening? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . eight. different Viral Ion Channels and Blockers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nine. hypothesis of Binding websites within the Cytoplasmic website . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196 197 198 199 199 two hundred two hundred two hundred two hundred 15. Virus Ion Channels shaped via Vpu of HIV-1, the 6K Protein of Alphaviruses and NB of Influenza B Virus Peter W. Gage, Gary Ewart, Julian Melton, and Anita Premkumar 1.

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